Preprints and In Press

Suzuki, S., Ryan, J., Cheong, Y. F., Kragel, P.A., & Treadway, M.T. (2023). Bidirectional dynamics of mood, reward, effort and exploration in naturalistic task environments. PsyArxiv

Rotem D Whitton A.E., Treadway, M.T., Rutherford A. Kumar P., Ironside M., Kaiser, R. Ren, B. Pizzagalli, D.A. (in press). Brain-based graph-theoretical predictive modeling to map the trajectory of anhedonia, impulsivity, and hypomania from the human functional connectome. Neuropsychopharmacology.

Pratt, D. N., Treadway, M. T., Strauss, G. P., Mittal, V. A. (in press). Diminished Differentiation of Rewards in Individuals at Clinical High-Risk for Psychosis. Eur Arch Psychiatry Clin Neurosci.

Whitton, A.E., Cooper, J.A., Merchant, J.T., Treadway, M.T. & Lewandowski, K.E. (in press). Using computational phenotyping to identify divergent strategies for effort allocation across the psychosis spectrum. Schizophrenia Bulletin.

Etuk, S.M., Treadway, M.T. (in press) Towards translational biomarkers for motivation: A commentary on Noback et al. Cognitive, Affective, and Behavioral Neuroscience.

2024

Ryan, J.R., Treadway, M.T. (2024). Transdiagnostic or disorder-specific? Altered reinforcement learning in depression and schizophrenia. Brain, 147, 5-6. (edited) 

2023

Fani, N., Treadway, M.T. (2023). Potential applications of temporal interference deep brain stimulation for the treatment of transdiagnostic conditions in psychiatry. Neuropsychopharmacol.

Swales, D.A., Lozza-Fiacco, S., Andersen, E.H., Cooper, J.A., Treadway, M.T., Xia, K., Schiller, C.E., Girdler, S.S. and Dichter, G.S., (2023). Hormone sensitivity predicts the beneficial effects of transdermal estradiol on reward-seeking behaviors in perimenopausal women: A randomized controlled trial. Psychoneuroendocrinology, p.106339.

Whitton, A., Kumar, P., Treadway, M., Rutherford, A., Ironside, M., Foti, D., Fitzmaurice, G. and Du, F., Pizzagalli, D.A. (2023). Distinct profiles of anhedonia and reward processing and their prospective associations with quality of life among individuals with mood disorders. Molecular Psychiatry.

Treadway, M. T. (2023). Treating Motivational and Consummatory Aspects of Anhedonia. Focus, 21(3), 278-280.

Kragel, P.A., Treadway, M.T., Admon, R., Pizzagalli, D.A. and Hahn, E.C. (2023). A mesocorticolimbic signature of pleasure in the human brain. Nature Human Behaviour, pp.1-12.

Hossein, S., Cooper, J.A., DeVries, B.A.M., Nuutinen M.R., Hahn, E.C., Kragel, P.A., Treadway, M.T. (2023). Effects of Acute Stress and Depression on Functional Connectivity between Prefrontal Cortex and the Amygdala. Molecular Psychiatry. 19:1-1.

Treadway, M.T. (2023). Computational Psychiatry and Lived Experience of Mental Illness. Nature Reviews Psychology, 2(2):67-8.

2022

Bekhbat, M., Li, Z., Mehta, N. D., Treadway, M. T., Lucido, M. J., Woolwine, B. J., ... & Felger, J. C. (2022). Functional connectivity in reward circuitry and symptoms of anhedonia as therapeutic targets in depression with high inflammation: evidence from a dopamine challenge study. Molecular Psychiatry, 1-9.

Treadway, M.T., Salamone, J.D. (2022). Vigor, Effort-Related Aspects of Motivation and Anhedonia. Curr Top Behav Neurosci, epub May 4th

Miller, A.H., Lucido, M.J., Bekhbat, M., Mehta, N.D., Chen, X., Treadway, M.T., Felger, J.C. and Haroon, E. (2022). Inflammation and treatment resistance: Mechanisms and treatment implications. In Managing Treatment-Resistant Depression (pp. 237-251).

Bekhbat, M., Treadway, M. T., & Felger, J. C. (2022). Inflammation as a Pathophysiologic Pathway to Anhedonia: Mechanisms and Therapeutic Implications.

2021

Lucido, M.J., Bekhbat, M., Goldsmith, D.R., Treadway, M.T., Haroon, E., Felger, J.C., Miller, A.H. (2021) Aiding and abetting anhedonia: impact of inflammation on the brain and pharmacologic implications. Pharmacology Reviews 73, 1084-1117.

Cooper, JA, Nuutinen, MR, Lawlor, VM, DeVries, B, Barrick, EM, Hossein, S, Hahn, E, Cole, DC, Leonard, CV, Teer, AP, Shields, GS, Slavich, GM, Ongur, D, Jense, JE, Du, F,  Pizzagalli, DA, & Treadway, MT. (2021). Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression. Nature Communications.

Hoots, J.K., Webber, H.E., Nunez, C., Cooper, J.A., Lopez-Gamundi, P., Lawlor, V.M., Lane, S.D., Treadway, M.T. & Wardle, M.C. (2021) Acute drug effects differentially predict desire to take amphetamine again for work and recreation. Psychopharmacology, 1-12.

Suzuki, S., Kamps, F., Dilks, D.D., Treadway, M.T. (2021). Two scene navigation systems dissociated by deliberate versus automatic processing. Cortex 140, 199-209.

Suzuki, S., Lawlor, V.M., Cooper, J.A., Arulpragasam, A.R., Treadway, M.T. (2021). Distinct regions of striatum underlying effort, movement initiation and effort discounting. Nature Human Behavior 5, 378-388

Whitton, A.E., Kumar, P., Treadway, M.T., Rutherford, A.V., Ironside, M.L., Foti, D., Fitzmaurice, G. Du, F., Pizzagalli, D.A. (in press). Mapping disease course across the mood disorder spectrum through a Research Domain Criteria (RDoC) framework. Biological Psychiatry: Clinical and Cognitive Neuroscience.

Bowyer, C., Brush, C.J., Threadgill, H., Harmon-Jones, E., Treadway, M.T., Patrick, C.J., Hajcak, G. (2021). The effort-doors task: examining the temporal dynamics of effort-based reward processing using ERPs. Neuroimage, 228.

Bondy, E., Norton, S.A., Voss, M., Marks, R.B., Boudreaux, M.J., Treadway, M.T., Oltmanns, T.F., Bogdan, R. (2021). Inflammation is associated with future depressive symptoms among older adults. Brain, Behavior and Immunity: Health 13, 100226

2020

Gene signatures in peripheral blood immune cells related to insulin resistance and low tyrosine metabolism define a sub-type of depression with high CRP and anhedonia. M Bekhbat, MT Treadway, DR Goldsmith, BJ Woolwine, E Haroon, AH Miller, JC Felger. Brain, Behavior, and Immunity. (2020).

2019

Can’t or Won’t? Immunometabolic Constraints on Dopaminergic Drive. MT Treadway, J Cooper and A Miller. Trends in Cognitive Sciences, (2019). 10.1016.2019.03.003.

Effortful goal-directed behavior in schizophrenia: Computational subtypes and associations with cognition. JA Cooper, DM Barch, LF Reddy, WP Horan, MF Green, MT Treadway. Journal of Abnormal Psychology, (2019). 128 (7), 710.

Depression genetic risk score is associated with anhedonia-related markers across units of analysis. G Guffanti, P Kumar, R Admon, MT Treadway, MH Hall, M Mehta, S Douglas, AR Arulpragasam, DA Pizzagalli. Translational Psychiatry, (2019).

Neurobiological Reward-Related Abnormalities Across Mood Disorders. AE Whitton, MT Treadway, ML Ironside, DA Pizzagalli. The Oxford Handbook of Positive Emotion and Psychopathology, (2019), 223.

Effort-based decision-making impairment in patients with clinically-stabilized first-episode psychosis and its relationship with amotivation and psychosocial functioning. Wing Chung Chang, Angel On Ki Chu, Michael T Treadway, Gregory P Strauss, Sherry Kit Wa Chan, Edwin Ho Ming Lee, Christy Lai Ming Hui, Yi Nam Suen, Eric Yu Hai Chen. European Neuropsychopharmacology, (2019).

2018

The impact of stress and major depressive disorder on hippocampal and medial prefrontal cortex morphology. EL Belleau, MT Treadway, and DA Pizzagalli. Biological Psychiatry 18 (2018), 10.1016/j.biopsych.2018.09.031.

Anhedonia in depression: biological mechanisms and computational models. JA Cooper, AR Arulpragasam, and MT Treadway. Current Opinion in Behavioral Sciences 22 (2018), 128-135.

Common and dissociable neural activity following mindfulness-based stress reduction and relaxation response programs. G Sevinc, BK Hölzel, J Hashmi, J Greenberg, A McCallister, MT Treadway, ML Schneider, JA Dusek, J Carmody, and SW Lazar. Psychosomatic Medicine 80 (2018), 439-451.

Examining the role of repetitive negative thinking in relations between positive and negative aspects of self-compassion and symptom improvement during intensive treatment. LP Wadsworth, M Forgeard, KJ Hsu, S Kertz, MT Treadway, and T Björgvinsson. Cognitive Therapy and Research 42 (2018), 236-249.

Social motivation in schizophrenia: the impact of oxytocin on vigor in the context of social and nonsocial reinforcement. D Fulford, MT Treadway, and J Woolley. Journal of Abnormal Psychology 127 (2018), 116-128.

Corticoinsular circuits encode subjective value expectation and violation for effortful goal-directed behavior. AR Arulpragasam, JA Cooper, MR Nuutinen, and MTTreadway. Proceedings of the National Academy of Sciences 115 (2018), E5233-E5242.

Inflammation-associated alterations in corticostriatal circuit function in breast cancer: relationship with motivational and motor deficits and fatigue. J Felger, MT Treadway, Z Li, E Haroon, MA Torres, and AH Miller.Psychosomatic Medicine 80, (2018), A145-A146.

2017

Willingness to expend effort toward reward and extreme ambitions in bipolar I disorder. SL Johnson, BA Swerdlow, MT Treadway, JA Tharp, and CS Carver. Clinical Psychological Science 5 (2017), 943-951.

Frontostriatal and dopamine markers of individual differences in reinforcement learning: a multi-modal investigation. RH Kaiser, MT Treadway, DW Witten, P Kumar, F Goer, L Murray, M Beltzer, P Pechtel, A Whitton, AL Cohen, NM Alpert, GE Fakhri, MD Normandin, and DA Pizzagalli. Cerebral Cortex (2017), 1-10.

Reduced willingness to expend effort for reward in obesity: link to adherence to a 3‐month weight loss intervention. F Mata, MT Treadway, A Kwok, H Truby, M Yücel, JC Stout, and A Verdejo‐Garcia. Obesity 25 (2017), 1676-1681.

Distinct trajectories of cortisol response to prolonged acute stress are linked to affective responses and hippocampal gray matter volume in healthy females. R Admon, MT Treadway, L Valeri, M Mehta, S Douglas and D. Pizzagalli Journal of Neuroscience (2017), 1175-17.

Working hard for oneself or others: Effects of oxytocin on reward motivation in social anxiety disorder. JA Fanga, MT Treadway, and SG Hofmann. Biological Psychology 127 (2017), 157-162.

Reward processing, neuroeconomics, and psychopathology. DH Zald and MT Treadway. Annual Review of Clinical Psychology 13 (2017), 471-496.

Inflammation effects on motivation and motor activity: role of dopamine. JC Felger and MT Treadway. Neuropsychopharmacology 42 (2017), 216-241.

Lippopolysaccharide alters motivated behavior in a monetary reward task: a randomized trial. J Lasselin, MT Treadway, TE Lacourt, A Soop, MJ Olsson, B Karshikoff, S Paues-Göranson, J Axelsson, R Dantzer, and M Lekander. Neuropsychopharmacology 42 (2017), 801–810.

Vicarious effort-based decision-making in autism spectrum disorders. MG Mosner, JL Kinard, S McWeeny, JS Shah, ND Markiewitz, CR Damiano‑Goodwin, MR Burchinal, HJV Rutherford, RK Greene, MT Treadway, and GS Dichter. Journal of Autism and Developmental Disorders 47 (2017), 2992-3006.

Association between interleukin-6 and striatal prediction-error signals following acute stress in healthy female participants. MT Treadway, R Admon, A Arulpragasam, M Mehta, S Douglas, G Vitaliano, DP Olson, JA Cooper, and DA Pizzagalli. Biological Psychiatry 82 (2017), 570-577.

2016

Isolating biomarkers for symptomatic states: considering symptom–substrate chronometry. MT Treadway and CV Leonard. Molecular Psychiatry 21 (2016), 1180–1187.

Inflammation effects on motivation and motor activity: role of dopamine. JC Felger and MT Treadway. Neuropsychopharmacology REVIEWS (2016) 1–26.

Inflammatory markers are associated with decreased psychomotor speed in patients with major depressive disorder. DR Goldsmith, E Haroon, BJ Woolwine, MY Jung, EC Wommack, PD Harvey, MT Treadway, JC Felger, and AH Miller. Brain, Behavior, and Immunity 56 (2016), 281-288.

Clashing Diagnostic Approaches: DSM-ICD versus RDoC. SO Lilienfeld and MT Treadway. Annual Review of Clinical Psychology 12 (2016), 435-463.

Network analysis of depression and anxiety symptom relationships in a psychiatric sample. C Beard, AJ Millner, MJC Forgeard, EI Fried, KJ Hsu, MT Treadway, CV Leonard, SJ Kertz, and T Björgvinsson. Psychological Medicine 46 (2016), 3359-3369.

Inefficient effort allocation and negative symptoms in individuals with schizophrenia. JM McCarthy, MT Treadway, ME Bennet, and JL Blanchard. Schizophrenia Research 170 (2016), 278-284.

Effect of failure/success feedback and the moderating influence of personality on reward motivation. D Anand, KA Oehlberg, MT Treadway, and R Nusslock. Cognition and Emotion 30 (2016), 458-471.